Discovery of a Spin-Down State Change in the LMC Pulsar B0540-69

We report the discovery of a large, sudden, and persistent increase in the spin-down rate of B0540-69, a young pulsar in the Large Magellanic Cloud, using observations from the Swift and RXTE satellites. The relative increase in the spin-down rate of 36% is unprecedented for B0540-69. No accompanying change in the spin rate is seen, and no change is seen in the pulsed X-ray emission from B0540-69 following the change in the spin-down rate. Such large relative changes in the spin-down rate are seen in the recently discovered class of 'intermittent pulsars', and we compare the properties of B0540-69 to such pulsars. We consider possible changes in the magnetosphere of the pulsar that could cause such a large change in the spin-down rate.Comment: 6 pages, 2 figures, accepted for publication in ApJ Letter

Function and regulation of Rnd proteins in cortical projection neuron migration

The mammalian cerebral cortex contains a high variety of neuronal subtypes that acquire precise spatial locations and form long or short-range connections to establish functional neuronal circuits. During embryonic development, cortical projection neurons are generated in the areas lining the lateral ventricles and they subsequently undergo radial migration to reach the position of their final maturation within the cortical plate. The control of the neuroblast migratory behavior and the coordination of the migration process with other neurogenic events such as cell cycle exit, differentiation and final maturation are crucial to normal brain development. Among the key regulators of cortical neuron migration, the small GTP binding proteins of the Rho family and the atypical Rnd members play important roles in integrating intracellular signaling pathways into changes in cytoskeletal dynamics and motility behavior. Here we review the role of Rnd proteins during cortical neuronal migration and we discuss both the upstream mechanisms that regulate Rnd protein activity and the downstream molecular pathways that mediate Rnd effects on cell cytoskeleton

Processing and Linking Audio Events in Large Multimedia Archives: The EU inEvent Project

In the inEvent EU project [1], we aim at structuring, retrieving, and sharing large archives of networked, and dynamically changing, multimedia recordings, mainly consisting of meetings, videoconferences, and lectures. More specifically, we are developing an integrated system that performs audiovisual processing of multimedia recordings, and labels them in terms of interconnected “hyper-events ” (a notion inspired from hyper-texts). Each hyper-event is composed of simpler facets, including audio-video recordings and metadata, which are then easier to search, retrieve and share. In the present paper, we mainly cover the audio processing aspects of the system, including speech recognition, speaker diarization and linking (across recordings), the use of these features for hyper-event indexing and recommendation, and the search portal. We present initial results for feature extraction from lecture recordings using the TED talks. Index Terms: Networked multimedia events; audio processing: speech recognition; speaker diarization and linking; multimedia indexing and searching; hyper-events. 1

Detection of explosives vapours on quartz crystal microbalances: generation of very low-concentrated vapours for sensors calibration

AbstractA controlled vapours generator of explosives compounds has been evaluated for delivering low-concentrated vapours in order to determine the threshold of quartz crystal microbalances based chemical gas sensors

Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear.

The mammalian inner ear contains two sensory organs, the cochlea and vestibule. Their sensory neuroepithelia are characterized by a mosaic of hair cells and supporting cells. Cochlear hair cells differentiate in four rows: a single row of inner hair cells (IHCs) and three rows of outer hair cells (OHCs). Recent studies have shown that Math1, a mammalian homolog of Drosophila atonal is a positive regulator of hair cell differentiation. The basic helix-loop-helix (bHLH) genes Hes1 and Hes5 (mammalian hairy and Enhancer-of-split homologs) can influence cell fate determination by acting as negative regulators to inhibit the action of bHLH-positive regulators. We show by using reverse transcription-PCR analysis that Hes1, Hes5, and Math1 are expressed in the developing mouse cochleae. In situ hybridization revealed a widespread expression of Hes1 in the greater epithelial ridge (GER) and in lesser epithelial ridge (LER) regions. Hes5 is predominantly expressed in the LER, in supporting cells, and in a narrow band of cells within the GER. Examination of cochleae from Hes1(-/-) mice showed a significant increase in the number of IHCs, whereas cochleae from Hes5(-/-) mice showed a significant increase in the number of OHCs. In the vestibular system, targeted deletion of Hes1 and to a lesser extent Hes5 lead to formation of supernumerary hair cells in the saccule and utricle. The supernumerary hair cells in the mutant mice showed an upregulation of Math1. These data indicate that Hes1 and Hes5 participate together for the control of inner ear hair cell production, likely through the negative regulation of Math1

Cytogenetic investigation in Saanen and Alpine artificial insemination bucks. Identification of a Robertsonian translocation

The cytogenetic study of 224 AI Saanen and Alpine he-goats revealed the presence of a Saanen animal carrying a Robertsonian translocation. The chromosomes involved in this translocation were determined using G (GTG) and C (CBG) banding techniques. The chromosomes in question were identified as chromosomes 6 and 15.L’étude cytogénétique de 224 boucs d’insémination artificielle de races Saanen et Alpine a permis de mettre en évidence la présence d’un animal de race Saanen porteur d’une translocation robertsonienne. Les chromosomes impliqués dans cette translocation ont été déterminés à l’aide des techniques de marquage G (GTG) et C (CBG). Les chromosomes concernés sont le 6 et le 15

Finding and counting vertex-colored subtrees

The problems studied in this article originate from the Graph Motif problem introduced by Lacroix et al. in the context of biological networks. The problem is to decide if a vertex-colored graph has a connected subgraph whose colors equal a given multiset of colors $M$. It is a graph pattern-matching problem variant, where the structure of the occurrence of the pattern is not of interest but the only requirement is the connectedness. Using an algebraic framework recently introduced by Koutis et al., we obtain new FPT algorithms for Graph Motif and variants, with improved running times. We also obtain results on the counting versions of this problem, proving that the counting problem is FPT if M is a set, but becomes W[1]-hard if M is a multiset with two colors. Finally, we present an experimental evaluation of this approach on real datasets, showing that its performance compares favorably with existing software.Comment: Conference version in International Symposium on Mathematical Foundations of Computer Science (MFCS), Brno : Czech Republic (2010) Journal Version in Algorithmic

Rate distortion optimized graph partitioning for omnidirectional image coding

International audienceOmnidirectional images are spherical signals captured by cameras with 360-degree field of view. In order to be compressed using existing encoders, these signals are mapped to planar domain. A commonly used planar representation is the equirectangular one, which corresponds to a non uniform sampling pattern on the spherical surface. This particularity is not explored in traditional image compression schemes, which treat the input signal as a classical perspective image. In this work, we build a graph-based coder adapted to the spherical surface. We build a graph directly on the sphere. Then, to have computationally feasible graph transforms, we propose a rate-distortion optimized graph partitioning algorithm to achieve an effective trade-off between the distortion of the reconstructed signals, the smoothness of the signal on each subgraph, and the cost of coding the graph partitioning description. Experimental results demonstrate that our method outperforms JPEG coding of planar equirectangular images